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Immunohistochemically, an intense positive immunohistochemical staining of apoptotic marker caspase-3 and astrocytes activation marker glial fibrillary acidic protein (GFAP) in the examined tissues was noticed

To further explore the role of miR-339-5p in hemin-treated SH-SY5Y cells, mimics or inhibitors of miR-339-5p were transfected into SH-SY5Y cells ( Figure 3B )