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2.1 Cell cycle blockade Tumor-associated cell cycle defects are often driven by dysregulation of cyclins and cyclin-dependent kinases (CDKs) ( 2.2 Janus kinase-signal transducer and activator of transcription pathway JAK-STAT pathway plays a crucial role in various cellular processes, including tumor cell recognition and tumor-driven immune evasion ( 2.3 The phosphoinositide 3-kinase/protein kinase B pathway PI3K/AKT signaling pathway plays a critical role in tumor development and metastasis ( 2.4 The nuclear factor kappa-light-chain-enhancer of activated B cells pathway NF-B is a crucial regulator of tumor cell apoptosis, as well as tumor angiogenesis and invasion ( 3 Induction of tumor cell apoptosis after PA intervention Tumor cell apoptosis is a crucial process involving the programmed death of tumor cells under both physiological and pathological conditions, playing a significant role in tumor occurrence and development ( 3.1 Tumor suppressor protein p53 The p53 protein is a critical tumor suppressor, and its functional loss is often a prerequisite for the development of cancer ( 3.2 B cell lymphoma-2 protein family The high activation of Bcl-2, which exhibits anti-apoptotic effects, has been associated with the occurrence, progression, and prognosis of cancer ( 3.3 The endoplasmic reticulum ER plays a vital role in maintaining cellular homeostasis ( 3.4 Reactive oxygen species ROS are highly reactive oxygen-containing molecules with a short lifespan, and they play a significant role in inducing DNA damage and affecting the DNA damage response

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