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These include: Vitamin B12 deficiency due to reduced stomach capacity and decreased intrinsic factor production Iron deficiency resulting from reduced stomach acid and bypassing of the duodenum Calcium and Vitamin D deficiencies, potentially leading to osteoporosis Protein malnutrition if adequate protein intake is not maintained These issues can harm health if not treated with supplements and diet changes

Epub 2017 Dec 12

This implies that the presence of the adenosyl group or changes mediated through AdoCbl photochemistry that lead to the removal of the adenosyl group are important in this dark-inhibition and light-activation process