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Description

(2011) 6:e23366

PFK is inactive unless the cell produces fructose-2,6-bisphosphate, its allosteric activator which is bound to PFK and activates it to initiate glycolysis

& Walsh, E

Our data demonstrate that the adaptive metabolic response to 5FU is mediated through the inhibition of TS function, as we recapitulate these phenotypes by genetic silencing or targeted inhibition of TS using antifolates