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UCHL5 positively regulates Hedgehog signaling by removing ubiquitination of Smoothened, Frizzled class receptor (SMO) protein in cancer cells (Zhou et al., 2018)

However, recovery pathways are not the same as guaranteed recovery outcomes

Scientifica (Cairo) 2014: 768607

Building on the success of PIs, there has been focus on inhibiting protein degradation via inhibition of initial ubiquitin binding rather than the downstream proteasome complex (116)