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Immediate medical attention is required if taste changes are accompanied by: Severe, persistent vomiting preventing adequate fluid intake Signs of dehydration (dark urine, dizziness, decreased urination) Severe abdominal pain, particularly if persistent or worsening Symptoms of pancreatitis (severe upper abdominal pain radiating to the back, nausea, vomiting) Right upper quadrant pain, fever, or yellowing of skin/eyes (possible gallbladder disease) Symptoms of hypoglycemia (if also taking insulin or sulfonylureas): shakiness, sweating, confusion, irritability These symptoms may indicate serious adverse effects requiring urgent evaluation, including pancreatitis, gallbladder disease, gastroparesis, or severe dehydration

Chen Z, K

doi: 10.3390/v13102092 149 McMeansE.YangT

We next extended the analysis using Torin-1, an inhibitor of TORC1 and TORC2, which activates autophagy (Liu et al, 2010)