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However, in vitro studies have reported that VA and RA regulate T synthesis by promoting the expression of STAR and CYP17A1 in Leydig cells

The concept of dose stepping, using a higher dose for initial weight loss and then transitioning to a lower dose for maintenance, could become the standard treatment paradigm if the data supports it

Mechanisms of carbon tetrachloride toxicity

Therefore, this hypothesis would predict that GLS inhibition, similar to high expression of SLC7A11, should decrease intracellular glutamate level and promote H 2 O 2 -induced cell death, and that further depleting intracellular glutamate levels by combining GLS inhibition with SLC7A11 high expression should exacerbate H 2 O 2 -induced cell death