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This genetic alteration could serve as a diagnostic biomarker and may provide a target for therapeutic strategies aimed at modulating UBE3A expression levels

Oral NR supplementation in aged participants elevates the muscle NAD + metabolome, ameliorates metabolic dysfunction, depresses levels of circulating inflammatory cytokines and increases the anti-inflammatory molecule adiponectin in aged human

Although the exact cause is not always known, many cases are associated with compression of the trigeminal nerve by a blood vessel near its origin in the brainstem

Together, these results highlight MAGI3 as a clinically robust prognostic marker in ccRCC, relevant in both primary tumors and metastatic sites