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Brains from male mice but not female mice, treated with intranasal GHK-Cu, only showed a decreased trend for the presence of microglia, suggesting microglia are not a robust target for GHK-Cu at least under the experimental conditions of this study

This is attributed to its ability to stimulate the production of growth factors, promote angiogenesis (the formation of new blood vessels), and elevate the levels of other proteins that support tissue regeneration

Human biology operates through a network of tightly coordinated systems that allow cells to produce energy, communicate with each other, repair damage, and adapt to environmental stress

Additionally, T-IFNAR1 / tumor-bearing mice exhibited a better response to anti-PD- 1 than WT mice (Chen 2022), which also indicates that IFN-I impedes the efficacy of Immune checkpoint inhibition