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Quality Control and Pharmaceutical Standards The lack of standardized manufacturing protocols and regulatory quality oversight represents a major barrier to the safe and consistent clinical use of these peptides

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The low concentration, short half-life time with fast catabolism, and high reactivity of H 2 S might be challenging for the determination of endogenous H 2 S in vivo ( 2 S concentrations might result from variable detection methods as the different analysis technologies have distinct disadvantages, such as low sensitivity and specificity, complex preparation processes, and time-consuming procedures (Liu et al., 2012