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For me (my opinion only), for any patients need to initiate metformin therapy for a first time, as a healthcare professionals, we should advise him (and the physician) to check calcium level before treatment, and monitor both B12 and calcium levels during the treatment

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Using 2024 Overall Hospital Quality Star Rating data, implementing a cap of 4 stars in the lowest quartile of Safety of Care with at least three safety measures would result in 14 hospitals, out of 2,847 hospitals, receiving a lower Overall Hospital Quality Star Rating

Specifically, investigations on the Chinese Han population identified the rs10891644 variant as significantly associated with obesity susceptibility, with heterozygous individuals (GT type) exhibiting heightened vulnerability (Zhou et al., 2017)