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Stabilizing the closed S6 gate in the Shaker Kv channel through modification of a hydrophobic seal

3.1 Inhibition of Glutaminolysis by GLS Inhibitors The most straightforward approach for targeting glutaminolysis is the inhibition of GLS, which catalyzes the hydrolysis of glutamine to glutamate

Tau oligomers bind to cardiolipin, and this binding leads to the creation of membrane pores, causing mitochondrial swelling, cytochrome c release, and a reduction in membrane potential ( Figure 5 illustrates schematically the processes that eventually lead to Alzheimers disease, where the major players are Abeta, phosphorylated tau, and cardiolipin

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