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11A), and upregulated FOXO1A protein expression

The matrix metallopeptidase 2 (MMP2) that is known to break down the basement membrane was shown to promote cancer invasion 50,51

The intrinsic pathway is triggered by diverse intracellular stresses, such as DNA damage, metabolic perturbations, or endoplasmic reticulum stress, leading to mitochondrial outer membrane permeabilization (MOMP)