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Itd be interesting if Makary pushed back on this peptide deregulatory effort, but that seems relatively unlikely

10.3390/cancers13184703 143 RaisR.LembergK

Lactate inhibits NF-B signaling via Kla of RIG-I protein, leading to M2 macrophage polarization, which further suppresses Nlrp3 transcription, weakening CD8 + T cell antitumor activity and enhancing regulatory Treg immunosuppression