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Combination therapy leads to supraphysiologic levels of T3, which may lead to symptoms of thyrotoxicosis T3 has a shorter half-life than T4, which can lead to fluctuations in T3 levels, with a peak occurring shortly after dosing There is substantially more data from trials on the use of levothyroxine compared to combination therapy In my experience, patients who are on animal-derived combination products have already tried synthetic levothyroxine and feel that the combination products control their symptoms better

Therefore, supplementary LC can widely improve lipid metabolism and treat metabolic diseases mainly through promoting fatty acid (FA) -oxidation in land animals (Reference Owen, Nelssen and Goodband6Reference Stephens, Constantin-Teodosiu and Greenhaff10)

Choo BKM, Kundap UP, Kumari Y, Hue S-M, Othman I, Shaikh MF