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doi: 10.1159/000358664

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Artemisinin markedly diminishes the inflammatory response, primarily through downregulation of NF-B activity and its downstream cytokines, chemokines, and gene expressions, while also extending its regulatory effects to encompass transcription factors such as mTOR, activator protein-1 (AP1), HIF-1, STAT, and NRF-2, thereby enhancing its anti-inflammatory and immunomodulatory capabilities (240)