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References Center for Drug Evaluation and Research

IGF-1 is produced by the liver in response to GH stimulation and has a longer half-life than GH itself (~15 hours vs ~20 minutes), making it a more stable and reproducible measurement

Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice