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Tet1 and Tet2 mainly regulates the level of 5-hydroxymethylcytosine (5hmC) in the promoter region of primordial germ cell (PGCs) genes or 5hmC inside PGCs gene, while Tet3-mediates paternal active DNA demethylation [7, 64, 65, 89, 94, 134, 161]

GHK-Cu results appear gradually as skin firmness and elasticity improve

MicroRNAs can regulate human APP levels

To consider the dose- and time-dependency of the model, we also tested a low dose of 10 ng h 1 for 9 days (low dose, longer time), 100 ng h 1 for 3 days (high dose, shorter time) and an acute treatment for 24 h (3 1.5 g, every 8 h)