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In mice with diet-induced obesity, the administration of Lactobacillus lowered insulin resistance and improved glucose tolerance, potentially by alleviating endoplasmic reticulum stress in skeletal muscle, inhibiting macrophage activation, and enhancing GLUT4 expression (Tabuchi et al., 2003)

Recent work in Arabidopsis thaliana using cell cultures and in planta root hair assays showed that exogenous spermidine and spermine inhibit PCD at low doses but induce PCD at higher doses in a clearly dose-dependent manner 93