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204 Challenges and future directions toward clinical translation Although the gut microbiome shows immense potential as biomarkers for liver disease, its move toward large-scale clinical application still faces multiple challenges such as standardization, causality, and personalization

Acute lesions can be managed through a combination of medical and surgical treatments including the following: Local topical treatments such as resorcinol (a keratolytic/peeling agent) for nodules and abscesses and clindamycin (an antibiotic with anti-inflammatory properties) for pustules (40, 41)

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They act as the body's signaling molecules