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Gpx4 uses GSH as cofactor and is needed to prevent lipid peroxidation, which depends on ROS

Studies have shown that these compounds can affect the function of various immune cells, such as enhancing the activity of T lymphocytes and natural killer cells (NK cells), and regulating macrophage function, thereby enhancing the overall antitumor immune response of the body ( 3.2.3 Cell cycle regulation and DNA repair Carotenoids also inhibit tumor growth by regulating the cell cycle and promoting DNA damage repair

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Ling H, Spizzo R, Atlasi Y, Nicoloso M, Shimizu M, Redis RS, Nishida N, Gaf R, Song J, Guo Z, Ivan C, Barbarotto E, De Vries I, Zhang X, Ferracin M, Churchman M, van Galen JF, Beverloo BH, Shariati M, Haderk F, Estecio MR, Garcia-Manero G, Patijn GA, Gotley DC, Bhardwaj V, Shureiqi I, Sen S, Multani AS, Welsh J, Yamamoto K, Taniguchi I, Song MA, Gallinger S, Casey G, Thibodeau SN, Le Marchand L, Tiirikainen M, Mani SA, Zhang W, Davuluri RV, Mimori K, Mori M, Sieuwerts AM, Martens JW, Tomlinson I, Negrini M, Berindan-Neagoe I, Foekens JA, Hamilton SR, Lanza G, Kopetz S , Fodde R , Calin GA