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340 Binding immune complexes (ICs) to FcRIIa activates neutrophils, triggering cellular responses such as degranulation, cytoskeletal reorganization, production of ROS and inflammatory mediators, and the generation of NETs

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Pharmacologic inhibition of IL-6 signaling is attractive in the context of desensitization strategies, as animal models have shown that this therapy reduces alloantibody responses by inhibition of bone marrow plasma cells and induction of Treg cells (160)