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Saeko Onami, et al

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Introduction Branched-chain amino acids (BCAAs) comprise three essential amino acids, leucine, isoleucine, and valine, which all have multiple functions in the brain (Yudkoff, Figure 1), ultimately yielding acetyl coenzyme A (CoA) or succinyl CoA (Sperringer et al., Figure 1 Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by a heterogeneous pathology comprising defective protein clearance (Braak and Braak, de novo synthesized (Sperringer et al., The goals of this study were to perform the first functional profiling of BCAA metabolism in human astrocytes and identify metabolic alterations in BCAA metabolism in the pathophysiology of AD using human induced pluripotent stem cell-derived astrocytes and neurons

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