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In the REDEFINE 1 trial, CagriSema produced 20.4% body weight loss over 68 weeks

doi: 10.2337/dc19-0217 104 OldfieldLEvansARaoRGJenkinsonCPurewalTPsarelliEEet al

However, as the overexpression of MUP1 and MMP1 appears to also decrease cytosolic acidification of CYS4 -OE cells (Supplementary Figure 1A), their action may also involve other molecular mechanisms