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doi: 10.1016/s0022-3476(75)80975-9 32 Le ThiP

The accumulation of oxidative damage will eventually induce kinds of diseases, such as aging, initiate cancer, arteriosclerosis and heart disease

A striking example involves the Y-satellite RNA of CMV: Its derived siRNA targets the chlorophyll biosynthesis gene CHLI in tobacco, inducing leaf yellowing to reduce photosynthetic efficiency and conserve energy

In the FLS of RA patients, the expression of anti-apoptotic mediators such as Bcl-2, Bcl-xL, Mcl-2 and FLICE inhibitory protein (FLIP) is upregulated, whereas the expression of pro-apoptotic proteins such as TRAIL, p53 up-regulator of apoptosis (PUMA) and BAX is downregulated