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Furthermore, the extract upregulated the expression of aquaporin 5 (AQP5) in the lacrimal glands and inhibited the activation of MAPK and NF-B signaling pathways, leading to decreased production of pro-inflammatory cytokines [89]

Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium

The second study, which evaluated the effects of 50 mg guarana extract twice daily in 75 breast cancer patients experiencing chemotherapy-related fatigue, found guarana superior to placebo for relieving fatigue (de Oliveira Campos 2011)