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Beside the amplification of GPx activity, melatonin also deactivates H2O2 free radicals in a dose-dependant manner which follows the formation of AFMK (N-acetyl-N-formyl-5-methoxykynuramine) metabolites.51 Interestingly, it was noticed that reaction products (of melatonin with free radicals), such as AFMK and 3-OHM, were also found to possess the strong free radical scavenging capacity which corroborate the cascade of free radicals scavenging by melatonin.52,53 Consequently, scavenging of all these potent free radicals, contributes into the melatonin's potential to offset the free radical mediated cellular toxicity in kidney

Dong JY, Zhang YH, Tong J, Qin LQ

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, Ketogenic diets and thermal pain: dissociation of hypoalgesia, elevated ketones, and lowered glucose in rats