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There are six main substance groups that cause damage to peripheral sensory and motor neurons, resulting in development of CIPN: the platinum-based antineoplastics (particularly oxaliplatin and cisplatin), the vinca alkaloids (particularly vincristine and vinblastine), the epothilones (ixabepilone), the taxanes (paclitaxel, docetaxel), the proteasome inhibitors (bortezomid) and immunomodulatory drugs (thalidomide)

10.3390/antiox12112012 131 SiavashyS.SoltaniM.Ghorbani-BidkorbehF.FallahN.FarnamG.MortazaviS

Neurotoxicology 18 (1), 137145

With the exception of parenteral nutrition, nutrients and other dietary factors are generally ingested orally