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Moreover, the BRCA1 loss mutation, like oncogene activation (RAS, NF-B, TGF-), in cancer cells will drive the initiation of metabolic symbiosis phenotype between tumor cells and fibroblasts in both primary and metastatic cancers (226)

Curr Drug Metab 8:315323 Back SA, Gan X, Li Y, Rosenberg PA, Volpe JJ (1998) Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion