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This demonstrates the existence of IRS-1 dependent and -independent pathways of insulin/IGF-1 signaling

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Additionally, radiation can disrupt skin microcirculation, leading to vascular permeability and vasoconstriction, resulting in skin tissue ischemia and hypoxia 19

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Regulation of O6-methylguanine-DNA methyltransferase by methionine in human tumour cells

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doi: 10.1093/jn/117.7.1303

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