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the study data were incomplete, lacking the main outcome measures

Additionally, melatonin may modulate the hyperphosphorylation of the microtubule-associated tau protein, a process leading to the formation of NFTs characteristic of AD [32]

Since circulating HTY in humans is mainly present as sulfate and glucuronide conjugates after oral intake, future studies should also clarify whether these metabolites contribute to the reported antidiabetic and anti-obesity effects (Fig