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This study has confirmed that the N86Y allele is critical in MQ drug response (Table 3)

This increases to 2.6ug/d in pregnancy, and 2.8ug/d when breastfeeding (2)

The term NNMT inhibitors as used herein refers small molecule chemical entities that inhibit the enzymatic activity of NNMT, and includes the compounds of Formula I and Formula IA as well as compounds in Tables 1-3