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Third, mutant-IDH1 inhibitors, including FDA-approved AG-120, are potent wild-type IDH1 inhibitors under low Mg 2+ and low glucose conditions

Generating sufficient safety evidence would require large-scale clinical trials involving thousands of participants

Appl Biochem Biotechnol 172:595609 Cicero LL, Madesis P, Tsaftaris A, Piero ARL (2015) Tobacco plants over-expressing the sweet orange tau glutathione transferases (CsGSTUs) acquire tolerance to the diphenyl ether herbicide fluorodifen and to salt and drought stresses

To analyze the RNA expression levels of pro-inflammatory cytokines and chemokines in the rectum, which is the primary UC lesion site, qRT-PCR was performed on the 3rd day after DSS administration