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Interestingly, metformin attenuates obesity in old mice by increasing mucin production and goblet cell mass in the gut

Curr Drug Targets 20:12171226

2019 Mar 1;22(3):247-52

As SnCE1 Y212A shows the strongest processing, its existence as monomer, as shown by analytical SEC, together with being non-acetylated, might account for the improved autoproteolytic processing compared to SnCE1 C256A and wild type SnCE1