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Description

Evidence from Wang Hongbo et al

Overexpression of REST inhibited Mn-increased pro-inflammatory cytokines such as TNF- and proapoptotic proteins such as Bax, as well as attenuated Mn-decreased antiapoptotic Bcl-2 and antioxidant Nrf2, heme oxygenase 1 (HO-1), and catalase (CAT) in dopaminergic neurons (Pajarillo et al., 2020a)