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In osteosarcoma cell lines, central carbon metabolism, glutathione metabolism, the pentose phosphate pathway, and serine/glycine metabolism were upregulated 15,16,17

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1C,E), which Prx might reduce, possessing a disulfide bridge as a signal of oxidation rather than a sulfenic acid (not shown in the figure) cannot be excluded

These findings reveal that the therapeutic benefit of PD1/PD-L1 blockade is highly dependent on preexisting T-cell infiltration, a finding that was subsequently confirmed to be a common basis for the responses to various immunotherapies, such as CTLA-4 blockade and ICT treatment [106]