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Neutralizing antibody against PAI-1 attenuated p65 activation in IL-1 treated hepatocytes and blocked PAI-1 induction completely, suggesting the freely released PAI-1 is required to fully activate p65 and induce PAI-1

Transmission electron microscopy revealed mitochondrial membrane rupture, fragmentation, and mitochondrial cristae fragmentation and disappearance

Maywood N

Alternatively, different cells (LSCs and HT1080 cells in this case) may have distinct responses to the same stimulation, as has been shown by others 41