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Although more intensive regimens, such as docetaxel plus CF (DCF), have demonstrated improved survival [3, 4], CF-based therapy continues to play a central role in EC treatment, including in combination with immune checkpoint inhibitors for advanced or recurrent disease [5,6,7]

Results are typically observed after 36 months of consistent treatment , although the timeframe may vary depending on the severity of hair thinning, underlying causes of hair loss, and an individuals biological response to therapy

Statistical analysis Statistical analysis including unpaired t test and one-way ANOVA was performed using GraphPad Prism 9 in most figures unless otherwise stated in the figure legend

Relative quantification of polar metabolites was performed with XCalibur QuanBrowser 2.2 using a 5ppm mass tolerance and referencing an in-house library of chemical standards