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A key driver of neuronal injury is oxidative stress, which arises when the generation of reactive oxygen species (ROS) overwhelms the brains antioxidant defenses, one such defense being glutathione (GSH) (Dringen and Arend, 2025)

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This cycle, in addition to the demonstration of the potent antioxidant activity of bilirubin, [9] has led to the hypothesis that bilirubin's main physiologic role is as a cellular antioxidant