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A reaction that depletes cellular NAD+ pools and methyl donor availability

If a child lacks sufficient Vitamin B12, they might experience: (i) Developmental delays (such as late sitting, crawling, or walking) (ii) Speech delays or regression (like losing words they once knew) (iii) Poor social skills (such as decreased eye contact or not responding to their name) (iv) Behavioral issues (including irritability or mood swings) (v) Low muscle tone (making them feel floppy) These symptoms can be concerning, but they may stem from a lack of Vitamin B12, which affects how the brain and nervous system function

PubMed Thyssen JP, Menn T