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Description

Kim, J-H

37,38 A combination of Lactobacillus paracasei IMC 502 and L

Traditional therapies, primarily topical eye drops, are often associated with low adherence due to complex dosing regimens, side effects, and challenges with self-administration (229, 230)

Together, these processes illustrate that fibroblast activation and ECM remodeling are not merely secondary consequences of inflammation but are fundamental drivers of tophus maturation, structural stability, and long-term disease progression, highlighting them as critical therapeutic targets in chronic gout