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STAT3 and STAT5 have been reported to act by inhibiting the antitumor immune response by activating, at least in part, the production of inflammatory cytokines (IL-1, IL-17, IL-10, TGF-, or VEGF) and promoting tumor growth and metastasis (150)

While curtailing lactate mitigates lipid peroxidation, sparing membranes from 4-HNE assault, it risks starving cells of ATP in regions where mitochondria are irreparably damaged [210]

PMID: 40494050 Brain Behav A Preliminary Study of Effect of Melatonin on Inflammation and Hypoxia-Related Factors in a Mouse Model of Elastase-Induced Intracranial Aneurysm