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Lichen planus CDC | James Heilman, MD / Wikimedia Commons What it looks like : Purplish lesions on the inner arms, legs, wrists, or ankles can signify lichen planus, a skin rash triggered by an overreaction of the immune system

Figure 3 3.2.2 Pulmonary arterial hypertension Pulmonary arterial hypertension (PAH) is a multifactorial, chronic disease process that results in pulmonary arterial endothelial dysfunction and smooth muscular hypertrophy, leading to right ventricular failure and even death (Humbert et al., 2023

Concurrently, lowered Pol I activity triggers lipidome remodeling towards reduced abundance of damage-prone and lipotoxic phospholipids and fatty acids, with increased Pol I activity conferring the opposite effect on both mitochondrial stress and the lipidome