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The Journal of Nutrition, 146(1), 18

Insider's takeaway The Institute of Medicine has not established a tolerable upper intake level of B12 because studies show no adverse health effects when taking excess levels of B12, either through food or supplements

In a model of heart failure established by high methionine diet treatment, plasmatic Hcy level was elevated and an association between HHcy and activation of NF-B was disclosed [98]