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In a reaction catalyzed by -glutamylcysteine synthetase, L-cysteine and L-glutamate form -glutamylcysteine. By the addition of glycine, GSH is formed in a reaction catalyzed by glutathione synthetase. The catabolism of GSH is mainly catalyzed by -glutamyl transpeptidase (forming glutamate and cysteinylglycine) and dipeptidases (forming cysteine and glycine)

References 1 CaoD.LiuY.MaL.JinX.GuoG.TanR.et al

BWS iPSC-derived hepatocytes display increased ROS signatures A consequence of -oxidation is the generation of endogenous reactive oxygen species (ROS) 47,48 , which, among other effects, can lead to lipid peroxidation