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Adequate copper status is necessary for optimal DAO activity. Magnesium: Involved in hundreds of enzymatic reactions, including those supporting methylation and overall inflammatory balance. Zinc: Supports toxic histamine aldehyde clearance, which is essential for full clearance of histamine. Glutathione: Acts as your body's master antioxidant that helps modulate mast cell activity

Clinical suspicion plays a fundamental role in the diagnostic process, and is higher in patients at higher risk, including vegetarians, malnourished patients, older people, and patients who have malabsorption syndromes or have undergone gastrectomy or bariatric surgery

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However, it declines with age, so adding a supplement can help support the processes, even as production drops off