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With the use of IV GTN in the treatment of ADHF, tolerance refers to loss of hemodynamic effect over a 24-h period as measured by pulmonary capillary wedge pressure [7]

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We also used a virus-based approach to examine this neural connection between the small intestine and the brain, specifically by infusing a retrograde AAV2/Retro-hSyn-Cre virus into the small intestine and a Cre-dependent AAV-DIO-mCherry virus into the DMV of C57 mice (Fig