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Description

Measuring and reducing off-target activities of programmable nucleases including CRISPR-Cas9

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Cranberries, blackberries, chokeberries, black grapes, gooseberries, bilberries, red raspberries, blueberries, blackcurrants, and strawberries are rich sources of ACNs

doi: 10.1016/j.lfs.2023.122060

Methods: As a model of chronic liver injury with Bak/Bax activation, we generated hepatocyte-specific Bcl-xL(-/-) Mcl-1(+/-) mice, which showed massive hepatocyte apoptosis and severe elevation of serum ALT levels at the age of 6 weeks