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Genomic sections displaying sequence conservation over time within a single viral species or evolutionary conservation between members of the coronavirus family despite high mutation rates are indicative of essential regions of the viral genome that are functionally constrained, such as the fusion peptide within the spike S2 region [68, 69]

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However, matching was not performed because unequal variables in this study, including surgical approach and extent of lymphadenectomy, did not affect long-term nutritional outcomes and survival in patients with early gastric cancer [16,17]