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Megaloblastic anemia, which is characterized by an abundance of abnormally large and dysfunctional red blood cells, is most commonly caused by folate and/or B12 deficiency

Mitochondrial dysfunction regulates multiple programmed pathways, including apoptosis, pyroptosis and ferroptosis, thereby promoting tubular cell loss, inflammation and kidney dysfunction

At the same time, they reduce antioxidant activity by decreasing GSH content and CAT activity [90, 91], enhancing DNA destruction, and stimulating different signals, resulting in apoptosis and cell death [92, 93]

The key benefit of activated charcoal is its porous nature, which makes it effective for detoxing